Nouveaux biomarqueurs de la maladie coronaire, IL-6, Il-10, LDL oxidées , MMP-2, MMP-9, sICAM-1, sICAM-3, sUPAR, sCD40L and MPO PDF
By:Aurélie Bedel
Published on 2007 by
The aim of our study is to evaluate diagnostic and/or prognostic value of biological markers implicated in atherogenesis or atherosclerotic lesion progression, in patients with acute coronary syndrome with troponin elevation, without angiographic lesion and initial and after 6-month follow-up endocoronary echographic measurements (IVUS). 31 patients were included and 10 biomarkers (IL-6, Il-10, oxidized LDL, MMP-2, MMP-9, sICAM-1, sICAM-3, sUPAR, sCD40L and MPO) were retrospectively measured on blood samples collected after hospital admission (M1) and after 6 months (M6). 13 patients presented an event during follow-up: angioplasty based on IVUS ( 4 patients at M1 and 4 patients after M6) and clinic events (5 patients). 3 blood samples can't be analysed at M6. Some markers seem to have an interest to improve coronary disease's therapeutic strategy, in complement of usual biological exploration
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